Media report · AI-ASSISTED BRIEF

USTC Releases Open-Source RNA Foundation Model structRFM, Published in Nature

Report publication 2026-11-05 · YYSI publication 2026-11-08

According to IT Home, The University of Science and Technology of China released structRFM, an open-source RNA sequence foundation model that incorporates secondary-structure knowledge into large-scale pretraining. Trained on about 21 million computationally annotated sequence-structure pairs, it improves secondary and tertiary structure prediction and functional inference tasks such as splice-site prediction. The team published the work in Nature and released the paired data, model weights and source code.